
Authors: Angela M Gutierrez, E Molly Frazar, Victoria Klaus, Pranto Paul, J Z Hilt
Grants: None Found
Abstract: Humans are constantly exposed to exogenous chemicals throughout their life, which can lead to a multitude of negative health impacts. Advanced materials can play a key role in preventing or mitigating these impacts through a wide variety of applications. The tunable properties of hydrogels and hydrogel nanocomposites (e.g., swelling behavior, biocompatibility, stimuli responsiveness, functionality, etc.) have deemed them ideal platforms for removal of environmental contaminants, detoxification and reduction of body burden from exogenous chemical exposures for prevention of disease initiation, and advanced treatment of chronic diseases, including cancer, diabetes, and cardiovascular disease. In this review, three main junctures where the use of hydrogel and hydrogel nanocomposite materials can intervene to positively impact human health are highlighted: (1) preventing exposures to environmental contaminants; (2) prophylactic treatments to prevent chronic disease initiation; (3) treating chronic diseases after they have developed. This article is protected by copyright. All rights reserved.
Conclusions: None
Copyrights: This article is protected by copyright. All rights reserved.
DOI: 10.1002/adhm.202101820
Journal: Advanced healthcare materials
Keywords: ['chronic diseases', 'hydrogel nanocomposites', 'hydrogels', 'remediations', 'therapeutics']
Methods: None
PMID: 34811960
Results: None
Title: Hydrogels and Hydrogel Nanocomposites: Enhancing Healthcare Through Human and Environmental Treatment.
PMCID: None
Publication Year: 2021
Publication Month: 11
Publication Day: 24
Author First: Angela
Author Last: Gutierrez
Name Search: Angela Gutierrez
Email: amgu232@g.uky.edu
First Author: Gutierrez, Angela M
Last Author: Hilt, J Z
Pub_Authors: 
Gutierrez, Angela M AM Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY, 40506, USA.
Superfund Research Center, University of Kentucky, Lexington, KY, 40506, USA.
Frazar, E Molly EM Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY, 40506, USA.
Superfund Research Center, University of Kentucky, Lexington, KY, 40506, USA.
Klaus, Victoria V Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY, 40506, USA.
Superfund Research Center, University of Kentucky, Lexington, KY, 40506, USA.
Paul, Pranto P Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY, 40506, USA.
Superfund Research Center, University of Kentucky, Lexington, KY, 40506, USA.
Hilt, J Z JZ Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY, 40506, USA.
Superfund Research Center, University of Kentucky, Lexington, KY, 40506, USA.

Authors: Anna G Hoover, Annie Koempel, W Jay Christian, Kimberly I Tumlin, Kelly G Pennell, Steven Evans, Malissa McAlister, Lindell E Ormsbee, Dawn Brewer
Grants: G08 LM013185, P30 ES026529, P42 ES007380, R01 ES032396
Abstract: None
Conclusions: None
Copyrights: None
DOI: None
Journal: Journal of Appalachian health
Keywords: []
Methods: None
PMID: 32095784
Results: None
Title: Appalachian Environmental Health Literacy: Building Knowledge and Skills to Protect Health.
PMCID: PMC7039621
Publication Year: 2020
Publication Month: 2
Publication Day: 26
Author First: Ann
Author Last: Koempel
Name Search: Ann Koempel
Email: ann.koempel@uky.edu
First Author: Hoover, Anna G
Last Author: Brewer, Dawn
Pub_Authors: 
Hoover, Anna G AG University of Kentucky College of Public Health.
Koempel, Annie A University of Kentucky Department of Dietetics and Human Nutrition.
Christian, W Jay WJ University of Kentucky College of Public Health.
Tumlin, Kimberly I KI University of Kentucky College of Public Health.
Pennell, Kelly G KG University of Kentucky College of Engineering.
Evans, Steven S Kentucky Water Resources Research Institute.
McAlister, Malissa M Kentucky Water Resources Research Institute.
Ormsbee, Lindell E LE University of Kentucky College of Engineering.
Brewer, Dawn D University of Kentucky Department of Dietetics and Human Nutrition.

Authors: Anna G Hoover, Annie Koempel, W Jay Christian, Kimberly I Tumlin, Kelly G Pennell, Steven Evans, Malissa McAlister, Lindell E Ormsbee, Dawn Brewer
Grants: G08 LM013185, P30 ES026529, P42 ES007380, R01 ES032396
Abstract: None
Conclusions: None
Copyrights: None
DOI: None
Journal: Journal of Appalachian health
Keywords: []
Methods: None
PMID: 32095784
Results: None
Title: Appalachian Environmental Health Literacy: Building Knowledge and Skills to Protect Health.
PMCID: PMC7039621
Publication Year: 2020
Publication Month: 2
Publication Day: 26
Author First: Anna
Author Last: Hoover
Name Search: Anna Hoover
Email: Anna.Hoover@uky.edu
First Author: Hoover, Anna G
Last Author: Brewer, Dawn
Pub_Authors: 
Hoover, Anna G AG University of Kentucky College of Public Health.
Koempel, Annie A University of Kentucky Department of Dietetics and Human Nutrition.
Christian, W Jay WJ University of Kentucky College of Public Health.
Tumlin, Kimberly I KI University of Kentucky College of Public Health.
Pennell, Kelly G KG University of Kentucky College of Engineering.
Evans, Steven S Kentucky Water Resources Research Institute.
McAlister, Malissa M Kentucky Water Resources Research Institute.
Ormsbee, Lindell E LE University of Kentucky College of Engineering.
Brewer, Dawn D University of Kentucky Department of Dietetics and Human Nutrition.

Authors: Anna G Hoover, Annie Koempel, W Jay Christian, Kimberly I Tumlin, Kelly G Pennell, Steven Evans, Malissa McAlister, Lindell E Ormsbee, Dawn Brewer
Grants: G08 LM013185, P30 ES026529, P42 ES007380, R01 ES032396
Abstract: None
Conclusions: None
Copyrights: None
DOI: None
Journal: Journal of Appalachian health
Keywords: []
Methods: None
PMID: 32095784
Results: None
Title: Appalachian Environmental Health Literacy: Building Knowledge and Skills to Protect Health.
PMCID: PMC7039621
Publication Year: 2020
Publication Month: 2
Publication Day: 26
Author First: Dawn
Author Last: Brewer
Name Search: Dawn Brewer
Email: dawn.brewer@uky.edu
First Author: Hoover, Anna G
Last Author: Brewer, Dawn
Pub_Authors: 
Hoover, Anna G AG University of Kentucky College of Public Health.
Koempel, Annie A University of Kentucky Department of Dietetics and Human Nutrition.
Christian, W Jay WJ University of Kentucky College of Public Health.
Tumlin, Kimberly I KI University of Kentucky College of Public Health.
Pennell, Kelly G KG University of Kentucky College of Engineering.
Evans, Steven S Kentucky Water Resources Research Institute.
McAlister, Malissa M Kentucky Water Resources Research Institute.
Ormsbee, Lindell E LE University of Kentucky College of Engineering.
Brewer, Dawn D University of Kentucky Department of Dietetics and Human Nutrition.

Authors: Fan Chen, Jinpeng Liu, Robert M Flight, Kassandra J Naughton, Alexsandr Lukyanchuk, Abigail R Edgin, Xiulong Song, Haikuo Zhang, Kwok-Kin Wong, Hunter N B Moseley, Chi Wang, Christine F Brainson
Grants: NCI K22 CA201036, IRG-85-001-25, NCI R01 CA237643, 133123-RSG-19-081-01-TBG, NIGMS P20 GM121327-03, P30CA177558, NIGMS P20 GM121327-03
Abstract: Targeting the epidermal growth factor receptor (EGFR) with tyrosine kinase inhibitors (TKIs) is one of the major precision medicine treatment options for lung adenocarcinoma. Due to common development of drug resistance to first- and second-generation TKIs, third-generation inhibitors, including osimertinib and rociletinib, have been developed. A model of EGFR-driven lung cancer and a method to develop tumors of distinct epigenetic states through 3D organotypic cultures are described here. It is discovered that activation of the EGFR T790M/L858R mutation in lung epithelial cells can drive lung cancers with alveolar or bronchiolar features, which can originate from alveolar type 2 (AT2) cells or bronchioalveolar stem cells, but not basal cells or club cells of the trachea. It is also demonstrated that these clones are able to retain their epigenetic differences through passaging orthotopically in mice and crucially that they have distinct drug vulnerabilities. This work serves as a blueprint for exploring how epigenetics can be used to stratify patients for precision medicine decisions.
Conclusions: None
Copyrights: © 2021 The Authors. Advanced Science published by Wiley-VCH GmbH.
DOI: 10.1002/advs.202101999
Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Keywords: ['EGFR', 'alveolar', 'bronchiolar', 'lung cancer', 'organoids']
Methods: None
PMID: 34622577
Results: None
Title: Cellular Origins of EGFR-Driven Lung Cancer Cells Determine Sensitivity to Therapy.
PMCID: None
Publication Year: 2021
Publication Month: 10
Publication Day: 9
Author First: Hunter
Author Last: Moseley
Name Search: Hunter Moseley
Email: hunter.moseley@gmail.com
First Author: Chen, Fan
Last Author: Brainson, Christine F
Pub_Authors: 
Chen, Fan F Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA.
Liu, Jinpeng J Department of Internal Medicine, University of Kentucky, Lexington, KY, 40536, USA.
Flight, Robert M RM Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, 40536, USA.
Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA.
Naughton, Kassandra J KJ Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA.
Lukyanchuk, Alexsandr A Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA.
Edgin, Abigail R AR Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA.
Song, Xiulong X Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA.
Zhang, Haikuo H DNAtrix, 10355 Science Center Drive, Suite 110, San Diego, CA, 92121, USA.
Wong, Kwok-Kin KK Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York University, New York, NY, 10016, USA.
Moseley, Hunter N B HNB Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA.
Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, 40536, USA.
Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA.
Wang, Chi C Department of Internal Medicine, University of Kentucky, Lexington, KY, 40536, USA.
Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA.
Brainson, Christine F CF Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA.
Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA.

Authors: Anna G Hoover, Annie Koempel, W Jay Christian, Kimberly I Tumlin, Kelly G Pennell, Steven Evans, Malissa McAlister, Lindell E Ormsbee, Dawn Brewer
Grants: G08 LM013185, P30 ES026529, P42 ES007380, R01 ES032396
Abstract: None
Conclusions: None
Copyrights: None
DOI: None
Journal: Journal of Appalachian health
Keywords: []
Methods: None
PMID: 32095784
Results: None
Title: Appalachian Environmental Health Literacy: Building Knowledge and Skills to Protect Health.
PMCID: PMC7039621
Publication Year: 2020
Publication Month: 2
Publication Day: 26
Author First: Kelly
Author Last: Pennell
Name Search: Kelly Pennell
Email: kellypennell@uky.edu
First Author: Hoover, Anna G
Last Author: Brewer, Dawn
Pub_Authors: 
Hoover, Anna G AG University of Kentucky College of Public Health.
Koempel, Annie A University of Kentucky Department of Dietetics and Human Nutrition.
Christian, W Jay WJ University of Kentucky College of Public Health.
Tumlin, Kimberly I KI University of Kentucky College of Public Health.
Pennell, Kelly G KG University of Kentucky College of Engineering.
Evans, Steven S Kentucky Water Resources Research Institute.
McAlister, Malissa M Kentucky Water Resources Research Institute.
Ormsbee, Lindell E LE University of Kentucky College of Engineering.
Brewer, Dawn D University of Kentucky Department of Dietetics and Human Nutrition.

Authors: Anna G Hoover, Annie Koempel, W Jay Christian, Kimberly I Tumlin, Kelly G Pennell, Steven Evans, Malissa McAlister, Lindell E Ormsbee, Dawn Brewer
Grants: G08 LM013185, P30 ES026529, P42 ES007380, R01 ES032396
Abstract: None
Conclusions: None
Copyrights: None
DOI: None
Journal: Journal of Appalachian health
Keywords: []
Methods: None
PMID: 32095784
Results: None
Title: Appalachian Environmental Health Literacy: Building Knowledge and Skills to Protect Health.
PMCID: PMC7039621
Publication Year: 2020
Publication Month: 2
Publication Day: 26
Author First: Lindell
Author Last: Ormsbee
Name Search: Lindell Ormsbee
Email: lindell.ormsbee@uky.edu
First Author: Hoover, Anna G
Last Author: Brewer, Dawn
Pub_Authors: 
Hoover, Anna G AG University of Kentucky College of Public Health.
Koempel, Annie A University of Kentucky Department of Dietetics and Human Nutrition.
Christian, W Jay WJ University of Kentucky College of Public Health.
Tumlin, Kimberly I KI University of Kentucky College of Public Health.
Pennell, Kelly G KG University of Kentucky College of Engineering.
Evans, Steven S Kentucky Water Resources Research Institute.
McAlister, Malissa M Kentucky Water Resources Research Institute.
Ormsbee, Lindell E LE University of Kentucky College of Engineering.
Brewer, Dawn D University of Kentucky Department of Dietetics and Human Nutrition.

Authors: Angela M Gutierrez, E Molly Frazar, Victoria Klaus, Pranto Paul, J Z Hilt
Grants: None Found
Abstract: Humans are constantly exposed to exogenous chemicals throughout their life, which can lead to a multitude of negative health impacts. Advanced materials can play a key role in preventing or mitigating these impacts through a wide variety of applications. The tunable properties of hydrogels and hydrogel nanocomposites (e.g., swelling behavior, biocompatibility, stimuli responsiveness, functionality, etc.) have deemed them ideal platforms for removal of environmental contaminants, detoxification and reduction of body burden from exogenous chemical exposures for prevention of disease initiation, and advanced treatment of chronic diseases, including cancer, diabetes, and cardiovascular disease. In this review, three main junctures where the use of hydrogel and hydrogel nanocomposite materials can intervene to positively impact human health are highlighted: (1) preventing exposures to environmental contaminants; (2) prophylactic treatments to prevent chronic disease initiation; (3) treating chronic diseases after they have developed. This article is protected by copyright. All rights reserved.
Conclusions: None
Copyrights: This article is protected by copyright. All rights reserved.
DOI: 10.1002/adhm.202101820
Journal: Advanced healthcare materials
Keywords: ['chronic diseases', 'hydrogel nanocomposites', 'hydrogels', 'remediations', 'therapeutics']
Methods: None
PMID: 34811960
Results: None
Title: Hydrogels and Hydrogel Nanocomposites: Enhancing Healthcare Through Human and Environmental Treatment.
PMCID: None
Publication Year: 2021
Publication Month: 11
Publication Day: 24
Author First: Pranto
Author Last: Paul
Name Search: Pranto Paul
Email: ppa322@uky.edu
First Author: Gutierrez, Angela M
Last Author: Hilt, J Z
Pub_Authors: 
Gutierrez, Angela M AM Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY, 40506, USA.
Superfund Research Center, University of Kentucky, Lexington, KY, 40506, USA.
Frazar, E Molly EM Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY, 40506, USA.
Superfund Research Center, University of Kentucky, Lexington, KY, 40506, USA.
Klaus, Victoria V Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY, 40506, USA.
Superfund Research Center, University of Kentucky, Lexington, KY, 40506, USA.
Paul, Pranto P Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY, 40506, USA.
Superfund Research Center, University of Kentucky, Lexington, KY, 40506, USA.
Hilt, J Z JZ Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY, 40506, USA.
Superfund Research Center, University of Kentucky, Lexington, KY, 40506, USA.

Authors: Angela M Gutierrez, E Molly Frazar, Victoria Klaus, Pranto Paul, J Z Hilt
Grants: None Found
Abstract: Humans are constantly exposed to exogenous chemicals throughout their life, which can lead to a multitude of negative health impacts. Advanced materials can play a key role in preventing or mitigating these impacts through a wide variety of applications. The tunable properties of hydrogels and hydrogel nanocomposites (e.g., swelling behavior, biocompatibility, stimuli responsiveness, functionality, etc.) have deemed them ideal platforms for removal of environmental contaminants, detoxification and reduction of body burden from exogenous chemical exposures for prevention of disease initiation, and advanced treatment of chronic diseases, including cancer, diabetes, and cardiovascular disease. In this review, three main junctures where the use of hydrogel and hydrogel nanocomposite materials can intervene to positively impact human health are highlighted: (1) preventing exposures to environmental contaminants; (2) prophylactic treatments to prevent chronic disease initiation; (3) treating chronic diseases after they have developed. This article is protected by copyright. All rights reserved.
Conclusions: None
Copyrights: This article is protected by copyright. All rights reserved.
DOI: 10.1002/adhm.202101820
Journal: Advanced healthcare materials
Keywords: ['chronic diseases', 'hydrogel nanocomposites', 'hydrogels', 'remediations', 'therapeutics']
Methods: None
PMID: 34811960
Results: None
Title: Hydrogels and Hydrogel Nanocomposites: Enhancing Healthcare Through Human and Environmental Treatment.
PMCID: None
Publication Year: 2021
Publication Month: 11
Publication Day: 24
Author First: Victoria
Author Last: Klaus
Name Search: Victoria Klaus
Email: mxklaus@uky.edu
First Author: Gutierrez, Angela M
Last Author: Hilt, J Z
Pub_Authors: 
Gutierrez, Angela M AM Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY, 40506, USA.
Superfund Research Center, University of Kentucky, Lexington, KY, 40506, USA.
Frazar, E Molly EM Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY, 40506, USA.
Superfund Research Center, University of Kentucky, Lexington, KY, 40506, USA.
Klaus, Victoria V Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY, 40506, USA.
Superfund Research Center, University of Kentucky, Lexington, KY, 40506, USA.
Paul, Pranto P Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY, 40506, USA.
Superfund Research Center, University of Kentucky, Lexington, KY, 40506, USA.
Hilt, J Z JZ Department of Chemical and Materials Engineering, University of Kentucky, 177 F Paul Anderson Tower, Lexington, KY, 40506, USA.
Superfund Research Center, University of Kentucky, Lexington, KY, 40506, USA.
